Format of Presentation

Poster to be presented the Friday of the conference

Abstract

Following a recent study of the interaction between β-Cyclodextrin and thiabendazole,1 the present study focuses on the interaction between the same macrocyclic polymer and another guest molecule, carbendazim. To this effect, solubility tests using water, acetone, chloroform, acetonitrile, methanol and dimethyl sulfoxide deuterated were performed in order to determine the best NMR solvent for the analysis. We found that DMSO-d6 was appropriate.

In order to quantify the strength of the interaction between the two chosen molecules, stock solutions of both host and guest molecule were prepared, and 1H-NMR chemical shift titrations have been carried out. From the data obtained, we are determining the binding constant (Ka) applying the Rose-Drago Method. Calculated binding constants using NMR spectroscopy will be compared to those obtained by other analytical methods.

1 Albert Guillem Adserias Rodriguez; Nuclear Magnetic Resonance Spectroscopy Study of the Binding Interaction between β-Cyclodextrin and Thiabendazole: A Supramolecular Inclusion Complex.

Department

Chemistry

Faculty Advisor

Dipesh Prema

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Study of the Binding Interaction between β-Cyclodextrin and Carbendazim using Nuclear Magnetic Resonance Chemical Shift Titrations

Following a recent study of the interaction between β-Cyclodextrin and thiabendazole,1 the present study focuses on the interaction between the same macrocyclic polymer and another guest molecule, carbendazim. To this effect, solubility tests using water, acetone, chloroform, acetonitrile, methanol and dimethyl sulfoxide deuterated were performed in order to determine the best NMR solvent for the analysis. We found that DMSO-d6 was appropriate.

In order to quantify the strength of the interaction between the two chosen molecules, stock solutions of both host and guest molecule were prepared, and 1H-NMR chemical shift titrations have been carried out. From the data obtained, we are determining the binding constant (Ka) applying the Rose-Drago Method. Calculated binding constants using NMR spectroscopy will be compared to those obtained by other analytical methods.

1 Albert Guillem Adserias Rodriguez; Nuclear Magnetic Resonance Spectroscopy Study of the Binding Interaction between β-Cyclodextrin and Thiabendazole: A Supramolecular Inclusion Complex.

 

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