Presentation Title

Capillary Electrophoretic Simultaneous Separation of Bisphenol Analogues

Format of Presentation

Poster to be presented the Friday of the conference

Abstract

Bisphenol A (BPA) and its structural analogues are used in the production of polycarbonate plastics, epoxy resins, and personal care products. Some of these analogues including BPA, BPS, and BPF are proven to have endocrine disruptive effects in humans and animal species in very low concentrations. Many studies have reported bisphenols as an environmental contaminant, showing increased concentrations in air, water, soil, sediment, and organism tissues. The attempt to replace BPA with structural bisphenol analogues such as, BPAF, BPF, BPP, BPS, and BPZ has resulted in increased concern with these unstudied compounds and their effects on the body and environment. This project sought to optimize a simultaneous separation method for 13 bisphenol analogues (BPA, BPAF, BPB, BPBP, BPC, BPE, BPF, BPFL, BPG, BPM, BPP, BPA, BPZ) using capillary electrophoresis. The optimization of experimental parameters such as pH, concentration of buffer, applied voltage, and the addition of organic modifiers including methanol, ß-cyclodextrin, and acetonitrile was explored. This method was designed with the goal that it could be coupled with extraction methods of suspected bisphenol-containing products and successfully separating and identifying the analogues present.

Department

Chemistry

Faculty Advisor

Kingsley Donkor

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Capillary Electrophoretic Simultaneous Separation of Bisphenol Analogues

Bisphenol A (BPA) and its structural analogues are used in the production of polycarbonate plastics, epoxy resins, and personal care products. Some of these analogues including BPA, BPS, and BPF are proven to have endocrine disruptive effects in humans and animal species in very low concentrations. Many studies have reported bisphenols as an environmental contaminant, showing increased concentrations in air, water, soil, sediment, and organism tissues. The attempt to replace BPA with structural bisphenol analogues such as, BPAF, BPF, BPP, BPS, and BPZ has resulted in increased concern with these unstudied compounds and their effects on the body and environment. This project sought to optimize a simultaneous separation method for 13 bisphenol analogues (BPA, BPAF, BPB, BPBP, BPC, BPE, BPF, BPFL, BPG, BPM, BPP, BPA, BPZ) using capillary electrophoresis. The optimization of experimental parameters such as pH, concentration of buffer, applied voltage, and the addition of organic modifiers including methanol, ß-cyclodextrin, and acetonitrile was explored. This method was designed with the goal that it could be coupled with extraction methods of suspected bisphenol-containing products and successfully separating and identifying the analogues present.