Presentation Title

Interaction Study Between Benzimidazole Fungicides and β-Cyclodextrin by Affinity Capillary Electrophoresis

Format of Presentation

Poster to be presented the Friday of the conference

Abstract

Most fungicides are dissolved in an aqueous medium for the purpose of increased biological activity. However, benzimidazole fungicides such as carbendazim, fuberidazole, and thiabendazole are mainly limited in their usage by not being very soluble in water. β-cyclodextrin is a large glucose polymer with a hydrophobic interior and a hydrophilic exterior. As such, β-cyclodextrin can form guest-host complexes with many molecules. This complex has the possibility of being more water soluble than the original molecules by themselves. β-cyclodextrin is a molecule that can form a complex with the benzimidazole fungicides. Therefore, complexation of the benzimidazole fungicides with β-cyclodextrin may be able to increase the water solubility, which could increase their fungicide action. The analytical technique that was used to determine the interactions of these molecules is affinity capillary electrophoresis. The expected outcomes are the binding constants of carbendazim, fuberidazole, and thiabendazole with β-cyclodextrin. The stability of the complex and the solubility of the fungicide in the presence of β-cyclodextrin can be determined with the help of the calculated binding constant.

Department

Chemistry

Faculty Advisor

Kingsley Donkor

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Interaction Study Between Benzimidazole Fungicides and β-Cyclodextrin by Affinity Capillary Electrophoresis

Most fungicides are dissolved in an aqueous medium for the purpose of increased biological activity. However, benzimidazole fungicides such as carbendazim, fuberidazole, and thiabendazole are mainly limited in their usage by not being very soluble in water. β-cyclodextrin is a large glucose polymer with a hydrophobic interior and a hydrophilic exterior. As such, β-cyclodextrin can form guest-host complexes with many molecules. This complex has the possibility of being more water soluble than the original molecules by themselves. β-cyclodextrin is a molecule that can form a complex with the benzimidazole fungicides. Therefore, complexation of the benzimidazole fungicides with β-cyclodextrin may be able to increase the water solubility, which could increase their fungicide action. The analytical technique that was used to determine the interactions of these molecules is affinity capillary electrophoresis. The expected outcomes are the binding constants of carbendazim, fuberidazole, and thiabendazole with β-cyclodextrin. The stability of the complex and the solubility of the fungicide in the presence of β-cyclodextrin can be determined with the help of the calculated binding constant.