Presentation Title

The Impact of High Intensity Exercise on Carotid Artery Longitudinal Kinetics

Format of Presentation

Poster to be presented the Friday of the conference

Abstract

Longitudinal kinetics (LOKI) describe the bidirectional movement of the inner lining of arteries. With each cardiac cycle an anterograde movement occurs in early systole, followed by a retrograde movement later in systole and a second anterograde movement in diastole. Prostaglandins are powerful local vasodilators and availability is reduced with ibuprofen (IBU) administration. Our aim was to determine the impact of high intensity cycling exercise and concurrent prostaglandin inhibition on longitudinal displacement. A ramp incremental test on a cycle ergometer was used to determine VO2max, ventilatory threshold (VT) and respiratory compensation (RC) points of participants. An intensity of 33% of the difference between VT and RC was calculated for subsequent trials. On two separate days, participants either ingested IBU or echinacea (control) two hours before testing. Testing began with a 5-minute warm-up immediately followed by 45 minutes of the high-intensity exercise. Three 5-s ultrasound video clips of the carotid artery were obtained immediately before, after and 45 minutes after testing. We used speckle tracking software to analyze longitudinal movement of 4-10 cardiac cycles. A 2-way RM-ANOVA was used to assess differences between conditions at the various time-points. There was no significant difference between conditions, but exercise reduced LOKI immediately and 45 minutes after testing (Pre: 11.8 ± 3.2 Post I: 9.3 ± 1.7, Post 45: 9.4 ± 2.2, p < 0.01). This suggests that complex interactions between sympathetic nervous activity, shear and cardiac dynamics alter longitudinal movements; however, more comprehensive analyses of anterograde and retrograde movements need to be assessed.

Department

Biological Sciences

Faculty Advisor

Mark Rakobowchuk

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The Impact of High Intensity Exercise on Carotid Artery Longitudinal Kinetics

Longitudinal kinetics (LOKI) describe the bidirectional movement of the inner lining of arteries. With each cardiac cycle an anterograde movement occurs in early systole, followed by a retrograde movement later in systole and a second anterograde movement in diastole. Prostaglandins are powerful local vasodilators and availability is reduced with ibuprofen (IBU) administration. Our aim was to determine the impact of high intensity cycling exercise and concurrent prostaglandin inhibition on longitudinal displacement. A ramp incremental test on a cycle ergometer was used to determine VO2max, ventilatory threshold (VT) and respiratory compensation (RC) points of participants. An intensity of 33% of the difference between VT and RC was calculated for subsequent trials. On two separate days, participants either ingested IBU or echinacea (control) two hours before testing. Testing began with a 5-minute warm-up immediately followed by 45 minutes of the high-intensity exercise. Three 5-s ultrasound video clips of the carotid artery were obtained immediately before, after and 45 minutes after testing. We used speckle tracking software to analyze longitudinal movement of 4-10 cardiac cycles. A 2-way RM-ANOVA was used to assess differences between conditions at the various time-points. There was no significant difference between conditions, but exercise reduced LOKI immediately and 45 minutes after testing (Pre: 11.8 ± 3.2 Post I: 9.3 ± 1.7, Post 45: 9.4 ± 2.2, p < 0.01). This suggests that complex interactions between sympathetic nervous activity, shear and cardiac dynamics alter longitudinal movements; however, more comprehensive analyses of anterograde and retrograde movements need to be assessed.