Presentation Title

Rabies! An Investigation Into the Toehold Switch as a Sensor

Format of Presentation

Poster to be presented Friday March 31, 2017

Abstract

Rabies is a disease of the central nervous system caused by the Rabies virus. Although a vaccine is available, Rabies causes thousands of human deaths a year, mostly in developing countries. Current methods to test for Rabies are costly, time consuming, and not sensitive enough to identify the disease early enough for treatment. A novel mechanism of virus identification that has shown promise in Ebola and Zika virus applications is the toehold switch. Toehold switches are RNA-based constructs that allow the visual identification of genomic targets of interest based on the specific binding of a trigger sequence. My project aims to develop and test a new toehold switch for the identification of Rabies virus.

Department

Biological Sciences

Faculty Advisor

Don Nelson

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Rabies! An Investigation Into the Toehold Switch as a Sensor

Rabies is a disease of the central nervous system caused by the Rabies virus. Although a vaccine is available, Rabies causes thousands of human deaths a year, mostly in developing countries. Current methods to test for Rabies are costly, time consuming, and not sensitive enough to identify the disease early enough for treatment. A novel mechanism of virus identification that has shown promise in Ebola and Zika virus applications is the toehold switch. Toehold switches are RNA-based constructs that allow the visual identification of genomic targets of interest based on the specific binding of a trigger sequence. My project aims to develop and test a new toehold switch for the identification of Rabies virus.